The Premier League leaders have been in inspired form since their 1-1 draw with West Brom back in December, extending their winning streak to 18 in all competitions with a 1-0 victory over Arsenal on Sunday.
They face a Monchengladbach team struggling for form, on the other hand, having won just one of their last four matches.
The Germans, who finished fourth in the Bundesliga last season to qualify for the Champions League, are down in eighth this season, nine points off the qualification places.
City are the heavy favourites to come through what is expected to be a routine last-16 clash, but their recent history in the competition would tell you to expect the unexpected.
With the intriguing match-up looming, Sportsmail takes you through the important information you need to know.
Pep Guardiola has guided Manchester City to 18 straight victories in all competitions
Monchengladbach vs Man City: When and where is it?
The Champions League round of 16 first-leg clash between Borussia Monchengladbach and…